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5-Methoxy-N,N-dimethyltryptamine (also known as 5-MeO-DMT) is a naturally-occurring psychedelic substance of the tryptamine class. It is structurally related to DMT and 5-HO-DMT (bufotenin) and is reputed to produce the most powerful and intense psychedelic states within the entire class. 5-MeO-DMT produces its effects by binding to serotonin receptors in the brain.

The synthesis and psychoactive effects were documented by Alexander Shulgin in his 1997 book TiHKAL ("Tryptamines I Have Known and Loved"). Recent studies have demonstrated its capacity to induce mystical experiences and there is growing interest in exploring its potential therapeutic effects.

Subjective effects include unity and interconnectedness, time distortion, conceptual thinking, euphoria, and ego loss. 5-MeO-DMT's psychedelic effects are best compared to DMT in terms of intensity (extreme) and duration (very short). However, it generally lacks a visual geometry component and tends to produce more physical euphoria as well as even stronger transpersonal or mystical-like effects (e.g. ego loss) than DMT.

AN USER EXPERIENCE ABOUT 5-MeO-DMT:
" ... Nothing can describe the peak of the peak of 5-MeO-DMT. No words, and no thoughts. The only way to understand what it is like is to experience it: there is, and can never be, a substitute. It’s the epitome of any psychedelic possibility can that exist at any given time in our known reality as human beings. I no longer consider it a “drug”, regardless of what it literally would be classified as. It’s an unlocking of an experience that was not fully meant to be experienced by anyone who could not handle the intensity and the immediate erasing of the ego from all consciousness. There is a reason a chemical agent (natural or otherwise) is required to attain such mind states as these. Not only for the safety of the psychology of those who do not wish to experience a fully blown “alternate” reality that can be achieved, but also as an “optional” gateway for those who believe they are ready to ascend into a place of such power and vulnerable awe.

5-MeO-DMT does not show me everything.
5-MeO-DMT “makes” me everything. "

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How to Buy 5-MeO-DMT Freebase

You can buy 5-MeO-DMT Freebase and other research chemicals here at LizardLabs. All of our chemicals are third party lab tested. If you wish to see HNMR results for 5-MeO-DMT Freebase or any other chemical, just email us at

Responsible Research with 5-MeO-DMT Freebase

Always practice responsible research. You should read and educate yourself before undertaking research with any chemical. The Psychonaut Wiki has some very helpful resources and information on 5-MeO-DMT Freebase , so does The Third Wave. Never conduct research with a chemical without learning about it first.

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5-MeO-DMT Freebase and all other products are strictly for research purposes only and not for human consumption.

Store 5-MeO-DMT Freebase in a cool, dry place away from sunlight.

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5-MeO-DMT Freebase stock last updated at: November 2024

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